Carol Fuzeti Elias

The paper reanalyzes single-cell RNA sequencing data to identify two distinct Pmch-expressing neuronal populations in the MPOA of lactating mice, showing lactation-associated transcriptional changes and functional relevance.

This study identifies PMvDAT neurons as a leptin-responsive subpopulation in the hypothalamus that dynamically regulates sexual maturation during puberty.

This study shows that glutamatergic signaling from leptin-responsive PMv neurons is essential for puberty and reproductive function in female mice.

The paper identifies leptin-hyperpolarized neurons in the PMv that coexpress DAT and prolactin receptor, and shows they inhibit reproduction via AgRP, with computational modeling linking these findings to metabolic control of reproduction.