José Donato

Reproductive experience promotes permanent body growth independently of growth hormone

This study shows that reproductive experience leads to permanent body growth in mice and humans, independent of growth hormone.

Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition

This study identifies PMvDAT neurons as a leptin-responsive subpopulation in the hypothalamus that dynamically regulates sexual maturation during puberty.

Profile of proteins involved in iron homeostasis and energy metabolism in multiple organs of leptin-deficient mice

This study examines protein changes in iron homeostasis and energy metabolism across multiple organs in leptin-deficient mice, revealing tissue-specific disruptions in iron and metabolic regulation with age.

Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food

Reproductive neuronal circuitry in adaptive changes of energy balance

The paper identifies leptin-hyperpolarized neurons in the PMv that coexpress DAT and prolactin receptor, and shows they inhibit reproduction via AgRP, with computational modeling linking these findings to metabolic control of reproduction.

POMC-specific knockdown of Tril reduces body adiposity and increases hypothalamic leptin responsiveness

The paper identifies Tril as a mediator of high-fat diet effects in POMC neurons, showing that its knockdown reduces adiposity and increases leptin responsiveness in the hypothalamus.