Author

Irina Ritsch

Scripps Research InstituteORCID 0000-0001-9889-8397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Jane DysoniD· 2 shared Peter E. WrightiD· 2 shared Daniel ScholliD· 1 shared Elisabeth LehmanniD· 1 shared Frédéric H.‐T. AllainiD· 1 shared Gabriel C. LanderiD· 1 shared Gunnar JeschkeiD· 1 shared Leonidas EmmanouilidisiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

H. Jane DysonORCID

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3 papers

Recent·Most cited

From Hummingbird to Elephant: Amyloid Formation in Natural Transthyretin Variants

Irina Ritsch, Daniel Scholl, Maria Rafiq, Maria A. Martinez‐Yamout, Gabriel C. Lander, H. Jane Dyson, Peter E. Wright

This study compares the aggregation behavior of TTR variants from hummingbirds and elephants under mechanical agitation, revealing differences linked to their physiological adaptations.

bioRxiv · Jul 15, 2026 · PreprintBiophysics

Aggregation of Transthyretin by Fluid Agitation

Irina Ritsch, H. Jane Dyson, Peter E. Wright

This study investigates how fluid agitation induces transthyretin (TTR) aggregation under near physiological conditions, revealing a mechanism involving tetramer dissociation and monomer misfolding.

Proceedings of the National Academy of Sciences · Mar 11, 2025Peer-reviewedBiophysics

Phase separation of hnRNP A1 upon specific RNA-binding observed by magnetic resonance

Irina Ritsch, Elisabeth Lehmann, Leonidas Emmanouilidis, Maxim Yulikov, Frédéric H.‐T. Allain, Gunnar Jeschke

The paper investigates how hnRNP A1 interacts with specific RNA and undergoes phase separation, using magnetic resonance techniques to observe structural changes and droplet formation.

bioRxiv · Mar 21, 2022 · PreprintMolecular Biology