Peter E. Wright

This study compares the aggregation behavior of TTR variants from hummingbirds and elephants under mechanical agitation, revealing differences linked to their physiological adaptations.

The paper investigates how linker length and composition in HIF-1 affect its binding affinity and competition with CITED2 for TAZ1, revealing the role of flexibility and electrostatic interactions in modulating the hypoxic switch.

This study identifies cpSRP43 as a thermo-switchable chaperone that coordinates light harvesting complex biogenesis by switching between closed and open states to support LHCP biogenesis and protect Chl biosynthesis enzymes.

This study investigates how fluid agitation induces transthyretin (TTR) aggregation under near physiological conditions, revealing a mechanism involving tetramer dissociation and monomer misfolding.

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.