Author

Allan E. Rettie

University of WashingtonORCID 0000-0001-9894-8753Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:variant effect prediction· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Douglas M. FowleriD· 3 shared Katherine A. SitkoiD· 3 shared Gabriel E. BoyleiD· 2 shared Melissa A. ChiassoniD· 2 shared Aisha Haley BianchiiD· 1 shared Ajeya DixoniD· 1 shared Alan F. RubiniD· 1 shared Clara J. AmorosiiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Douglas M. FowlerORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 6, 2023

Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff

Gabriel E. Boyle, Katherine A. Sitko, Jared Galloway…·Douglas M. Fowler

The paper uses deep mutational scanning to analyze CYP2C19 variants, revealing a tradeoff between substrate specificity and protein abundance.

3 citations

humanexperimental assay

𝕏 PostBluesky

GenomicsThe American Journal of Human GeneticsPeer-reviewedJul 26, 2021

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

Clara J. Amorosi, Melissa A. Chiasson, Matthew G. McDonald…·Maitreya J. Dunham

The paper characterizes CYP2C9 variant enzyme activity and abundance using Click-seq and VAMP-seq, finding that two-thirds of variants show decreased activity and abundance explains half the functional variation.

115 citationstop 1%

humanexperimental assay

𝕏 PostBluesky

GenomicseLifePeer-reviewedSep 1, 2020

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Melissa A. Chiasson, Nathan J. Rollins, Jason J. Stephany…·Douglas M. Fowler

The paper measures the effects of VKOR variants on abundance and activity in human cells, revealing its topology, active site, and the impact of human variants.

91 citationstop 2%

humanproteomics

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