Alexandre Laverré

IVA uses a small language model to perform local genomic variant interpretation, achieving high sensitivity but lower precision in identifying pathogenic variants.

RegEvol detects directional selection in regulatory sequences by linking transcription factor binding predictions to evolutionary models, identifying 5.1% of Drosophila regulatory regions under directional selection.

The paper examines gene expression variability across organs in three ray-finned fish species, finding that brain-biased genes show stable regulation despite inter-individual differences.

The paper quantifies Prdm9-independent recombination hotspots in 52 mammals, finding that these hotspots are common and often coexist with Prdm9-directed hotspots.

GOntact uses chromatin contact data to predict CRE target genes and their Gene Ontology enrichments, showing more specific functional annotations than genomic proximity.