Jing Zhai

IVA uses a small language model to perform local genomic variant interpretation, achieving high sensitivity but lower precision in identifying pathogenic variants.

The paper shows that microglia use Rank signaling to regulate GnRH function and the HPG axis, leading to hypogonadotropic hypogonadism when disrupted.

GenMasterTable is a desktop application that filters, summarizes, and visualizes large-scale annotated genetic variants, offering a user-friendly interface for non-programmers.

This study creates a single-cell atlas of human testicular development and NOA patients, revealing Sertoli cell maturation defects and potential therapeutic strategies.

The paper develops exact tests for variance components in longitudinal microbiome studies and applies them to HIV-infected patients, identifying associations between lung microbiome genera and lung function.