Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and Prolactin Gene Expression During Interval-Training Activities of Pituitary Cells
Ling Liu, Hai Dang Nguyen, Urmi Das, Samuel Sunday Ogunsola, Jiankun Yu, Lei Lei, Matthew Kung, Shervin Pejhan, Mojgan Rastegar, Jiuyong Xie
This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.
Nucleic Acids Research · Apr 14, 2024Peer-reviewedCell Biology