Samuel Sunday Ogunsola

The paper identifies a genomic signature, G-tract-AG motifs, that regulates transcriptome integrity and diversity through repression of AG usage and SNV-induced splicing activation.

This study shows 5-aza-cytidine promotes terminal polyadenylation site usage, increasing full-length transcripts in cancer cells by altering poly(A) site selection and related factors.

The paper identifies cancer-specific exonic fragments by analyzing differentially expressed exons and somatic SNVs, revealing their association with tumor suppressor genes and potential for antigen discovery.

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.