Jiuyong Xie

The paper identifies a genomic signature, G-tract-AG motifs, that regulates transcriptome integrity and diversity through repression of AG usage and SNV-induced splicing activation.

This study shows 5-aza-cytidine promotes terminal polyadenylation site usage, increasing full-length transcripts in cancer cells by altering poly(A) site selection and related factors.

The paper identifies cancer-specific exonic fragments by analyzing differentially expressed exons and somatic SNVs, revealing their association with tumor suppressor genes and potential for antigen discovery.

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.

The paper identifies widespread separation of the polypyrimidine tract from 3’ AG by G tracts in alternative exons across metazoa and plants, showing their role in alternative splicing and disease.