Hai Dang Nguyen

Contribution of HMGB1 to Keratinocyte inflammation in Recessive Dystrophic Epidermolysis Bullosa

This study investigates HMGB1's role in keratinocyte inflammation in RDEB, finding increased HMGB1 expression in wounds and partial suppression of inflammation by pharmacological inhibition.

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators

This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.

Specificity of Aberrant Exons in a Saturated Background of Differentially Expressed Exons

The paper identifies cancer-specific exonic fragments by analyzing differentially expressed exons and somatic SNVs, revealing their association with tumor suppressor genes and potential for antigen discovery.

A novel variant in ADPRS disrupts ARH3 stability and subcellular localization in childrenwith neurodegeneration and respiratory failure

This study identifies a novel ADPRS variant causing ARH3 dysfunction in children with neurodegeneration and respiratory failure, linking it to protein instability and mislocalization.

Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and Prolactin Gene Expression During Interval-Training Activities of Pituitary Cells

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.

Widespread separation of the polypyrimidine tract from 3’ AG by G tracts in association with alternative exons in metazoa and plants

The paper identifies widespread separation of the polypyrimidine tract from 3’ AG by G tracts in alternative exons across metazoa and plants, showing their role in alternative splicing and disease.