André T. Lopes

This study identifies CDKL5 as a kinase that phosphorylates nELAVL proteins, enhancing mRNA binding and protein synthesis, and shows its role in visual cortex development.

This study identifies impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons, linking Rab5 hyperactivation to endosomal dysfunction and ERK1/2 signalling deficits.

This study investigates how CDKL5 phosphorylation of MAP1S affects microtubule function and cognitive processes, showing impaired dynein motility and synaptic defects in mutant mice.

This study identifies CDKL5 as a kinase that phosphorylates Cav2.3, altering its function and contributing to neuronal excitability in CDKL5 deficiency disorder.