Author

Sandeep Kumar Botla

Karolinska InstitutetORCID 0000-0001-9937-0455Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Bernhard SchmiereriD· 2 shared Jussi TaipaleiD· 2 shared Emma Maria HaapaniemiiD· 1 shared Jenna PerssoniD· 1 shared Jilin ZhangiD· 1 shared Mikko M. TuruneniD· 1 shared Teemu KiviojaiD· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersGenomics

Bernhard SchmiererORCID

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2 papers

Recent·Most cited

GenomicsNature MedicinePeer-reviewedJun 8, 2018

✦ In-depth digest

Inhibition of p53 improves CRISPR/Cas-mediated precision genome editing

Emma Maria Haapaniemi, Sandeep Kumar Botla, Jenna Persson…·Jussi Taipale

Cas9-induced double-strand breaks trigger p53/p21/RB1-dependent G1 arrest in RPE-1 cells; transient p53 inhibition via MDM2 markedly raises homologous recombination precision editing efficiency.

1,265 citationstop 1%

humanCRISPR screen

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GenomicsMolecular Systems BiologyPeer-reviewedOct 1, 2017

CRISPR/Cas9 screening using unique molecular identifiers

Bernhard Schmierer, Sandeep Kumar Botla, Jilin Zhang…·Jussi Taipale

This paper introduces RSLs as UMIs to improve CRISPR/Cas9 screening reproducibility by enhancing precision and reducing required cells and sequencing reads.

85 citations

CRISPR screenexperimental assay

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