Author

Yikun Chen

Peking UniversityORCID 0000-0001-9957-7851Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Hailin PengiD· 1 shared Jiahe ZangiD· 1 shared Lie CheniD· 1 shared Wenjun GuoiD· 1 shared Xiaole Zhao· 1 shared Yongmei Tan· 1 shared

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2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiophysics

Hailin PengORCID

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1 paper

Recent·Most cited

BiophysicsCell DiscoveryPeer-reviewedOct 29, 2026

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation

Jiahe Zang, Yongmei Tan, Yikun Chen…·Lie Chen

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

DOI 10.1038/s41421-026-00936-y

humanstructural biology

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