Author

Wenjun Guo

Peking UniversityORCID 0009-0002-1789-7785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein structure prediction· 3 Organism:human· 2 Assay:protein structure· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jiahe ZangiD· 3 shared Lei CheniD· 2 shared Hailin PengiD· 1 shared Jiaxuan XuiD· 1 shared Lie CheniD· 1 shared Miao WeiiD· 1 shared Weiyu TaoiD· 1 shared Xiaole Zhao· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Jiahe ZangORCID

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3 papers

Recent·Most cited

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation

Jiahe Zang, Yongmei Tan, Yikun Chen, Wenjun Guo, Xiaole Zhao, Hailin Peng, Lie Chen

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

Cell Discovery · Oct 29, 2026Peer-reviewedBiophysics

Unveiling Eukaryotic Membrane Proteins in High Resolution Using Peptide Solubilization

Jiahe Zang, Yiting Shi, Weiyu Tao, Xiaoyu Liu, Wenjun Guo, Lei Chen

This paper introduces a peptide-based method to solubilize eukaryotic membrane proteins without detergents, enabling high-resolution structural studies.

Journal of Molecular Biology · Oct 7, 2025Peer-reviewedBiophysics

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1

Wenjun Guo, Miao Wei, Yunfeng Li, Jiaxuan Xu, Jiahe Zang, Yuezhou Chen, Lei Chen

Cryo-EM structures of human URAT1 with urate, benzbromarone, or verinurad (3.0 to 3.3 Å) reveal a rocker-switch transport cycle and inhibitors that lock the inward-facing state.

Nature Communications · Feb 10, 2025Peer-reviewedBiochemistry✦ In-depth digest