Author

Elizabeth Vargas

University of OregonORCID 0000-0001-9970-3512Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:protein structure· 1

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Kenneth E. PrehodaiD· 1 shared Rhiannon R. PenkertiD· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperBiochemistry

Kenneth E. PrehodaORCID

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1 paper

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedDec 18, 2024

A PDZ-kinase allosteric relay mediates Par complex regulator exchange

Elizabeth Vargas, Rhiannon R. Penkert, Kenneth E. Prehoda

The paper identifies an allosteric relay mechanism involving Par-6 PDZ domain and aPKC kinase domain interaction that regulates Par-3 and Cdc42 binding to the Par complex, explaining negative cooperativity in polarization.

4 citations

protein structureprotein sequence

𝕏 PostBluesky