Kenneth E. Prehoda

The paper shows the midbody facilitates asymmetric fate determinant activation in Drosophila neural stem cells by releasing determinants after nuclear division but before cell division completes.

This study shows that Lgl removes the Par complex from the membrane at mitotic exit in Drosophila neural stem cells, enabling proper asymmetric division by resetting polarity.

The paper shows that Arp2/3-driven membrane oscillations are essential for constricting intercellular bridges during Drosophila neural stem cell divisions when tension cannot be generated through migration.

The paper identifies an allosteric relay mechanism involving Par-6 PDZ domain and aPKC kinase domain interaction that regulates Par-3 and Cdc42 binding to the Par complex, explaining negative cooperativity in polarization.