SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction
Stephen E Flaherty, Olivier Bézy, Brianna LaCarubba Paulhus, LouJin Song, Mary E. Piper, Jincheng Pang, YoSon Park, Shoh M. Asano, Yu‐Chin Lien, John D Griffin, Andrew W. Robertson, Alan Opsahl, Dinesh K. Hirenallur-Shanthappa, Youngwook Ahn, Evanthia E. Pashos, , Zhidan Wu
This study identifies SPAG7 gene mutations in mice causing intrauterine growth restriction and adult obesity through reduced energy expenditure and mitochondrial dysfunction.
eLife · Jul 26, 2024Peer-reviewedMolecular Biology