Author

Stephen E Flaherty

Boston UniversityORCID 0000-0002-5050-6451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Alan Opsahl· 1 shared Alexander S. BanksiD· 1 shared Andrew W. RobertsoniD· 1 shared Brianna LaCarubba Paulhus· 1 shared Cadence J Vieira· 1 shared Deepti RamachandraniD· 1 shared Dinesh K. Hirenallur-ShanthappaiD· 1 shared Evanthia E. PashosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alan Opsahl

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2 papers

Recent·Most cited

GDF3 is an endogenous antagonist of the ActE-ALK7/ACVR2 pathway in adipocytes

Nagasuryaprasad Kotikalapudi, Deepti Ramachandran, Evelyn Y Zhou, James Anthony Howard, Cadence J Vieira, Wei‐An Chen, SARAH HSU, Kyung Cheul Shin, Shirish Naz, Zhenghui Gordon Jiang, Josep Maria Mercader, Thomas B. Thompson, Stephen E Flaherty, Paul M. Titchenell, Henning Fritz Kramer, Alexander S. Banks

This study identifies GDF3 as an endogenous inhibitor of the ActE-ALK7 pathway in adipocytes, showing its role in metabolic diseases like MASLD/MASH and suggesting GDF3 inhibition as a therapeutic target.

bioRxiv · Sep 24, 2026 · PreprintPhysiology

SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

Stephen E Flaherty, Olivier Bézy, Brianna LaCarubba Paulhus, LouJin Song, Mary E. Piper, Jincheng Pang, YoSon Park, Shoh M. Asano, Yu‐Chin Lien, John D Griffin, Andrew W. Robertson, Alan Opsahl, Dinesh K. Hirenallur-Shanthappa, Youngwook Ahn, Evanthia E. Pashos, , Zhidan Wu

This study identifies SPAG7 gene mutations in mice causing intrauterine growth restriction and adult obesity through reduced energy expenditure and mitochondrial dysfunction.

eLife · Jul 26, 2024Peer-reviewedMolecular Biology