Mary E. Piper

The paper uses single-nucleus multi-omics to study skeletal muscle changes in HFpEF patients and shows some molecular changes are reversible with lifestyle interventions.

This study demonstrates nanopore sequencing of 10x Genomics multiome libraries to capture full-length transcripts and identify TSS, showing concordance with short-read methods despite higher error rates.

The paper uses single-cell foundation models to identify genetic targets that reverse inflammation in endothelial cells by analyzing Perturb-seq data with and without proinflammatory stimulation.

This study identifies CD300LG as a receptor for triglyceride-rich lipoproteins, showing its role in postprandial lipid clearance and linking it to cardiovascular disease risk.

The paper uses multi-omics analysis to study molecular changes in the bladder after spinal cord injury in rats and identifies DNA damage response pathways modulated by inosine treatment.

This study identifies SPAG7 gene mutations in mice causing intrauterine growth restriction and adult obesity through reduced energy expenditure and mitochondrial dysfunction.

The paper shows that early life activity of RNA splicing factors and lipid metabolism determine the efficacy of longevity interventions in C. elegans.

The paper identifies a new source of cold-induced brown adipocytes, specifically vascular smooth muscle-derived progenitors expressing TRPV1.