Evanthia E. Pashos

The paper uses single-nucleus multi-omics to study skeletal muscle changes in HFpEF patients and shows some molecular changes are reversible with lifestyle interventions.

This study demonstrates nanopore sequencing of 10x Genomics multiome libraries to capture full-length transcripts and identify TSS, showing concordance with short-read methods despite higher error rates.

The paper uses single-cell foundation models to identify genetic targets that reverse inflammation in endothelial cells by analyzing Perturb-seq data with and without proinflammatory stimulation.

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

This study identifies SPAG7 gene mutations in mice causing intrauterine growth restriction and adult obesity through reduced energy expenditure and mitochondrial dysfunction.

The paper identifies cell-type specific splicing quantitative trait loci (sQTLs) in iPSCs and HLCs and shows they contribute to lipid level variation beyond what is captured by gene expression alone.

This study uses Mendelian randomization to examine if ACE inhibitors or cardiometabolic risk factors affect lung ACE2 and TMPRSS2 expression or plasma ACE2 levels, finding no overall association.