Miriam Matamales

The paper identifies D2-SPNs as transiently recruited during early learning to regulate D1-SPN dopamine signaling and improve action-outcome encoding under uncertainty.

The paper investigates how restoring D2-to-D1-neuron functional correspondence in aged mice enhances goal-directed action by manipulating striatal neurons.

The paper shows that variability in action timing, mediated by the M1[->]DLS circuit, is crucial for adapting action sequences in a two-lever instrumental task in mice.

This study maps the delayed effects of a single amphetamine dose on striatal cholinergic interneuron activity using p-rpS6 imaging in mice, showing subregional attenuation after 24 hours.

The paper shows that D2-SPNs suppress outdated D1-SPN plasticity in the striatum to update goal-directed learning.