Bernard W. Balleine

This study identifies distinct neural circuits for encoding and retrieving predictive learning in decision-making, showing the BLA-IL-NAc-S circuit is required for retrieval while BLA-NAc-S is only needed for encoding.

The paper identifies mPFC intratelencephalic neurons as critical for goal-directed learning through chemogenetic inhibition and synaptic plasticity analysis.

This study shows that nutrient-specific appetites control instrumental performance only when animals learn the value of rewards under different appetitive states.

This study shows that rats' lever-pressing behavior is goal-directed and influenced by their nutritional state, indicating that nutrient-specific appetites drive action choices.

This study investigates how CRFR1 in the SNpc affects dopamine activity and cognitive flexibility in rats under stress, showing hemispheric shifts in control mechanisms.

This study investigates the role of D1 and D2 neurons in the nucleus accumbens shell in stimulus-based decision-making using optogenetics in rats.

The paper shows that striatal neuroinflammation disrupts astrocyte function, leading to excessive goal-directed action control in rats.

The paper shows that thalamostriatal degeneration impairs goal-directed behavior in rats, but this deficit can be reversed by enhancing striatal cholinergic activity with selegiline.

This study investigates the effects of Immp2l knockdown in a mouse model of ASD and GTS, finding no impact on goal-directed learning or neuron density but increased stimulus-driven behaviour.

The paper shows that variability in action timing, mediated by the M1[->]DLS circuit, is crucial for adapting action sequences in a two-lever instrumental task in mice.

This study investigates how striatal dopamine encodes action-outcome relationships in rats, finding that dopamine release becomes lateralized to reflect the strength of these associations.

This study investigates the roles of direct and indirect pathway neurons in the posterior dorsomedial striatum in goal-directed learning and response flexibility.

This study identifies the role of amygdala-cortical interactions in striatal plasticity during goal-directed learning, showing that BLA input to PL is necessary for corticostriatal potentiation.

The paper shows that D2-SPNs suppress outdated D1-SPN plasticity in the striatum to update goal-directed learning.

This study shows that medial orbitofrontal cortex (mOFC) regulates instrumental conditioned punishment learning and retrieval, but not Pavlovian conditioned fear.

The paper introduces a recurrent neural network approach to model human decision-making and shows it outperforms traditional methods in predicting behavior in depression and bipolar disorder.

The paper introduces a method using recurrent neural networks to jointly model behavioral and neuroimaging data, revealing new insights into the temporal patterns of brain activity related to decision-making.

The paper uses fMRI and computational modeling to show that a Kalman filter best explains action-outcome learning, with the medial prefrontal cortex distinguishing action effects from background noise.