BiochemistrybioRxivPreprint
De Novo Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders
Cristina Montaner, Roberta Lucchi, Montserrat Escobar-Rosales…·Benjamí Oller‐Salvia
This paper designs de novo peptide masks to reversibly inactivate miniprotein binders, demonstrating their effectiveness in reducing EGFR antagonist binding and enabling conditional activation via stimuli like proteases or light.
DOI 10.1101/2025.02.25.639922