Author

Cristina Díaz‐Perlas

Institut Químic de SarriàORCID 0000-0002-9552-3896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Benjamí Oller‐SalviaiD· 2 shared David A. BakeriD· 2 shared Alex KangiD· 1 shared An‐Qi CheniD· 1 shared Anthony A. HymaniD· 1 shared Asim K. BeraiD· 1 shared Brian CoventryiD· 1 shared Cristina MontaneriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Benjamí Oller‐SalviaORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Computational design of metalloproteases

An‐Qi Chen, Kejia Wu, Hojae Choi, Preetham Venkatesh, Samuel J. Pellock, Nikita Hanikel, Hojeong Shin, Declan Evans, Kieran Didi, Lars L Schaaf, Cristina Díaz‐Perlas, Brian Coventry, Donghyo Kim, Seth M. Woodbury, Pengfei Ji, , David A. Baker

This paper designs de novo metalloproteases using RoseTTAFold Diffusion 2, achieving high activity and specificity for cleaving various substrates.

Nature · Oct 14, 2026Peer-reviewedBiochemistry

De Novo Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders

Cristina Montaner, Roberta Lucchi, Montserrat Escobar-Rosales, Marc Expòsit, Cristina Díaz‐Perlas, David A. Baker, Benjamí Oller‐Salvia

This paper designs de novo peptide masks to reversibly inactivate miniprotein binders, demonstrating their effectiveness in reducing EGFR antagonist binding and enabling conditional activation via stimuli like proteases or light.

bioRxiv · Feb 25, 2025 · PreprintBiochemistry