Author

Christian W. Heegaard

Aarhus UniversityORCID 0000-0002-7989-2624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Daniel WüstneriD· 3 shared Annette BurkhartiD· 2 shared Charlotte Laurfelt Munch RasmusseniD· 2 shared Maria SzomekiD· 2 shared Alice Dupont· 1 shared Alice Dupont Juhl· 1 shared Bartosz LaczekiD· 1 shared Christer S. EjsingiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

Daniel WüstnerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 18, 2026

Ganglioside profiling by ion mobility and mass spectrometry imaging identifies distinct biomolecular isomers in Niemann-Pick Disease

Signe Frost Frederiksen, Pelayo Álvarez Penanes, Charlotte Laurfelt Munch Rasmussen…·Ole Nørregaard Jensen

This study uses ion mobility and mass spectrometry imaging to identify distinct ganglioside isomers in Niemann-Pick Disease, showing therapeutic effects of gene therapy on lipid localization.

DOI 10.64898/2026.09.17.752326

mouseimaging

BiochemistryAnalytical ChemistryPeer-reviewedFeb 26, 2026

Live-cell imaging and lipidomics of low density lipoprotein containing intrinsically fluorescent cholesteryl esters

Alice Dupont Juhl, Richard R. Sprenger, Maciej Modzel…·Daniel Wüstner

This study uses live-cell imaging and lipidomics to track LDL-derived cholesteryl esters in cells, revealing their transport and metabolism kinetics.

1 citation

humanproteomics

NeurosciencebioRxivPreprintApr 15, 2024

Endothelial and neuronal engagement by AAV-BR1 alleviates neurological symptoms and cholesterol deposition in a mouse model of Niemann-Pick type C2

Charlotte Laurfelt Munch Rasmussen, Christian W. Heegaard, Maj Schneider Thomsen…·Annette Burkhart

AAV-BR1-NPC2 gene therapy reduces cholesterol deposition and neurological symptoms in NP-C2 mice by delivering NPC2 to brain endothelial cells and neurons.

DOI 10.1101/2024.04.15.589486

mouseexperimental assay

Cell BiologybioRxivPreprintNov 6, 2018

Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

Alice Dupont, Frederik W. Lund, Maria Louise V. Jensen…·Daniel Wüstner

This study uses fluorescence and X-ray microscopy to show NPC2 facilitates cholesterol export from endo-lysosomes, altering membrane trafficking and organelle structure.

DOI 10.1101/462481

humanfluorescence / live-cell microscopy