Author

Julio Cesar Ayala

Centers for Disease Control and PreventionORCID 0000-0001-9998-3091Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Concerta L. HolleyiD· 1 shared Grace A. BeggsiD· 1 shared Grace M. HooksiD· 1 shared John R. PerfectiD· 1 shared Maria A. SchumacheriD· 1 shared Richard G. BrennaniD· 1 shared Vijaya DhulipalaiD· 1 shared William Maurice ShaferiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Concerta L. HolleyORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedFeb 7, 2024

Hormonal steroids bind the Neisseria gonorrhoeae multidrug resistance regulator, MtrR, to induce a multidrug binding efflux pump and stress-response sigma factor

Grace M. Hooks, Julio Cesar Ayala, Concerta L. Holley…·Richard G. Brennan

This study identifies hormonal steroids that bind MtrR, a regulator in Neisseria gonorrhoeae, leading to reduced DNA binding and activation of multidrug efflux pumps and stress-response mechanisms.

19 citations

humanexperimental assay

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