Author

Richard G. Brennan

Duke UniversityORCID 0000-0001-7647-485XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. WashingtoniD· 3 shared Dennis C. KoiD· 2 shared Adi YonaiD· 1 shared Alexander R. Jenner· 1 shared Alfred T. HardingiD· 1 shared Angela G. JonesiD· 1 shared Anna LoksztejniD· 1 shared Benjamin H. SchottiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

E. WashingtonORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJan 20, 2026

Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity

Anna Loksztejn, Rajendra Upadhya, Eduardo A. Caro…·Jennifer K. Lodge

This study shows caspofungin accumulates in Cryptococcus mitochondria via cardiolipin binding, reducing its effectiveness and linking to cardiotoxicity in human cells.

1 citation

C. elegansexperimental assay

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MicrobiologymBioPeer-reviewedAug 25, 2025

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

Yi Miao, Vikas Yadav, William R. Shadrick…·E. Washington

This paper identifies 4456dh, a small molecule inhibitor of trehalose-6-phosphate synthase, which disrupts fungal thermal tolerance and virulence.

3 citations

fungi (other)experimental assay

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Molecular BiologybioRxivPreprintFeb 14, 2024

A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression

Margaret R. Gaggioli, Angela G. Jones, Ioanna Panagi…·Dennis C. Ko

2 citations

bacteria (other)proteomics

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GeneticsCell GenomicsPeer-reviewedNov 1, 2022

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus

Benjamin H. Schott, Liuyang Wang, Xinyu Zhu…·Dennis C. Ko

The paper identifies a nonsynonymous ERAP1 variant associated with increased susceptibility to influenza virus using scHi-HOST, a single-cell method for genetic susceptibility testing.

12 citations

humanscRNA-seq

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