Maxim Borisovich Kuznetsov

Antibody co-administration robustly improves proton therapy with radiosensitizing nanoparticles: a mathematical modeling study

This study uses mathematical modeling to show that co-administering antibodies with nanoparticle radiosensitizers improves proton therapy outcomes by enhancing nanoparticle distribution within tumors.

Ligand Discrimination in Immune Cells: Signal Processing Insights into Immune Dysfunction in ER+ Breast Cancer

The paper measures ligand discrimination errors and molecular noise in immune cells of ER+ breast cancer patients compared to healthy controls using a communication model.

Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines

The paper shows that lymphocytes and monocytes suppress IL-10R, IL-6R, and IL-2Rβγ signaling under high cytokine concentrations, mediated by cytokines that do not induce their own pSTATs.

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers

This paper develops a mathematical model to optimize targeted radionuclide therapy for multiple myeloma by identifying key principles for improving treatment efficacy while minimizing toxicity.