This paper investigates how age-related changes in frontoparietal brain activity mediate declines in fluid intelligence and identifies physical activity variety as a potential modifiable factor.

Journal of Neuroscience · Dec 5, 2022Peer-reviewedNeuroscience

Sensory attenuation is related to dopamine dose in Parkinson’s disease

Noham Wolpe, Jiaxiang Zhang, Cristina Nombela, James N. Ingram, Daniel M. Wolpert, Cam-CAN, LORRAINE KOMISARJEVSKY TYLER, Carol Brayne, Edward Thomas Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E. Matthews, William D. Marslen‐Wilson, , James Benedict Rowe

This study investigates how dopamine levels in Parkinson’s disease patients affect sensory attenuation during voluntary movements, finding a negative correlation with motor severity and a positive correlation with dopamine dose.

Scientific Reports · Oct 17, 2018Peer-reviewedNeuroscience

Strong and specific associations between cardiovascular risk factors and brain white matter micro- and macro-structure in health ageing

Delia Fuhrmann, David J. Nesbitt, Meredith A. Shafto, James Benedict Rowe, Darren Price, Andrew Gadie, LORRAINE KOMISARJEVSKY TYLER, Carol Brayne, Edward Thomas Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, , Laura Villis

This study examines the associations between cardiovascular risk factors and white matter structure in aging, finding that systolic blood pressure, diastolic blood pressure, and heart rate independently impact white matter health.

Neurobiology of Aging · Oct 11, 2018Peer-reviewedNeuroscience

Physical activity predicts population-level age-related differences in frontal white matter

Juho M Strömmer, Simon W Davis, Richard N. Henson, LORRAINE KOMISARJEVSKY TYLER, Cam-CAN, Carol Brayne, Edward Thomas Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E. Matthews, William D. Marslen‐Wilson, James Benedict Rowe, Meredith A. Shafto, , Laura Villis

The paper shows that physical activity preserves frontal white matter integrity and reduces age-related slowing in a population-based sample.

The Journals of Gerontology Series A · Oct 3, 2018Peer-reviewedNeuroscience

Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities

Dennis Chan, Meredith A. Shafto, Rogier Kievit, Fiona E. Matthews, Molly Spink, Michael Valenzuela, Cam-CAN, Richard N. Henson

Neurobiology of Aging · Jul 18, 2018Peer-reviewedNeuroscience

How are age-related difference in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults

Andrew Gadie, Meredith A. Shafto, Yue Leng, Cam-CAN, Rogier Kievit

This study investigates age-related differences in sleep quality and their associations with health outcomes in a UK cohort of 2406 adults, finding stronger links with mental health and u-shaped associations between sleep duration and mental health.

BMJ Open · Jul 31, 2017Peer-reviewedNeuroscience