Jarno Mäkelä

The paper introduces MIST, a framework that integrates single-molecule trajectory data with cellular context to improve molecular phenotyping in E. coli.

The paper shows that DnaK, a bacterial chaperone, dynamically reallocates in response to proteostasis demand, with acute stress increasing client engagement frequency and lifetime.

This study identifies pathogenic PTCD1 variants causing mitochondrial protein aggregation and cardiomyopathy by disrupting mitoribosome biogenesis and proteostasis.

The paper investigates how premature terminations and internal promoters affect operon responses during genome-wide stresses in bacteria.

The paper shows genome concentration limits transcription and affects proteome composition in E. coli, with effects detectable in nutrient-rich conditions.

The paper proposes a self-organising model explaining how bacterial chromosomal origins are positioned and partitioned during the cell cycle, showing agreement with experimental data.