Protein kinase F regulates the virulence of Mycobacterium tuberculosis
Flor Torres-Juárez, Shivangi Rastogi, David C. Young, Ashton T. Belew, Paul J. Baker, Viplov K. Biswas, Shannon E. Khan, Najib M. El-Sayed, David Branch Moody, Katrin D. Mayer-Barber, Volker Briken
This study shows that deleting the pknF gene in Mycobacterium tuberculosis increases its virulence in mice by enhancing production of the pro-virulence lipid PDIM and reducing host survival.
Infection and Immunity · Jul 27, 2026Peer-reviewedMicrobiology