PhysiologyBlood Red Cells & IronPeer-reviewed
Gardos potassium channel amplifies PIEZO1-TMEM16F coupling in red blood cells
Yui Chun Serena Wan, Martha D. Delahunty, Grace Lee…·Huanghe Yang
The paper identifies Gardos as an amplifier of PIEZO1-TMEM16F signaling in red blood cells, enhancing Ca2+ entry and PS externalization, and suggests it as a therapeutic target for diseases like sickle cell disease.
DOI 10.1016/j.brci.2026.100140