Sequential action of the nuclear Argonautes HRDE-1 and NRDE-3 promotes global transcriptional silencing during starvation in the nascent C. elegans germline
Emilie Chien, Mezmur D. Belew, W. Matthew Michael
The paper shows that HRDE-1 and NRDE-3 sequentially contribute to H3K9me3 hyperdeposition in C. elegans PGCs during starvation, leading to transcriptional silencing.