Tzu-Hao Harry Chao

SORDINO improves fMRI in awake mice by being silent, sensitive, specific, and resistant to motion artifacts, enabling better brain activity mapping.

The paper investigates excitation-inhibition balance dynamics in brain networks during naturalistic behavior in rats, finding coordinated E-I dynamics and transient imbalances linked to behavioral changes.

This paper develops a single-shot MRI sequence to simultaneously measure BOLD and slow CSF velocity, showing their spatial coupling in the brain.

This study examines how acute and chronic alcohol exposure affects calcium dynamics in the extended amygdala, showing changes in neuronal activity and coherence in a sex-specific manner.

This study investigates the default mode network (DMN) in freely exploring rats, finding it dynamically encodes spatial exploration behaviors and challenges the notion of the DMN being task-negative.

This study identifies neurochemical influences on fMRI response polarity in the striatum, showing opioidergic transmission contributes to negative signals while dopaminergic transmission is associated with positive signals.

The paper investigates the neuronal dynamics of the rodent default mode network and its interaction with the anterior insular cortex, revealing how salient stimuli modulate these networks.

This paper introduces spectral fiber-photometry methods to correct hemoglobin absorption artifacts in fluorescent sensor recordings, improving accuracy in measuring neuronal activity.

This study shows that chemogenetic activation of locus coeruleus norepinephrine neurons strengthens functional connectivity in the default mode network in mice.

This paper combines fMRI and fast-scan cyclic voltammetry to measure oxygen and dopamine dynamics alongside BOLD signals, revealing strong correlations between tissue oxygen and BOLD and identifying dopamine-responsive brain regions.

The paper shows that a small number of dysregulated adult-born neurons in the hippocampus disrupt brain-wide functional connectivity and spatial memory.