Thomas L. Kash

This study shows that chronic intermittent ethanol exposure in female mice leads to increased ethanol tolerance and persistent memory and anxiety-like behavioral changes during abstinence.

This study identifies region-specific serotonin signaling changes in the ACC and CeA after binge alcohol consumption, showing differential effects on reward and aversion behaviors.

A no-code clip-level active-learning platform combining pose, video and region-of-interest features trains rodent behavior classifiers (mean precision-recall AUC 0.90, 45 behaviors, eight assays) largely agreeing with expert human scoring.

This study shows that serotonin signaling in the orbitofrontal cortex influences alcohol consumption and aversion-resistant drinking in mice.

This study examines behavioral adaptations in female mice during fentanyl abstinence, finding persistent withdrawal symptoms and altered behaviors that may contribute to relapse vulnerability.

The paper identifies region-specific serotonergic and opioid receptor gene expression differences linked to distinct ethanol drinking phenotypes in mice.

This study examines sex differences in BNST CRF signaling during phasic and sustained fear in mice, finding sex-specific effects on fear responses and suggesting implications for anxiety treatment.

This study investigates the role of CRFR1 in the lateral hypothalamus during chronic binge drinking, finding that posterior LH CRFR1 knockdown increases alcohol consumption while also increasing anxiety and reducing sucrose preference.

This study shows that adolescent alcohol exposure reduces intrinsic excitability in adult male retrosplenial cortex pyramidal cells, suggesting vulnerability in males.

This study investigates the separate roles of CRF and GABA release from BNSTCRF neurons in ethanol self-administration in mice, finding CRF deletion reduces ethanol intake while GABA suppression affects motivation differently in males and females.

This study identifies a population of nociceptin-expressing neurons in the lateral septum that modulate binge-like alcohol consumption and shows sex-dependent effects of NOP receptor deletion.

This study shows that inhibiting CRF projections from the central amygdala to the lateral hypothalamus reduces binge-like ethanol drinking in male, but not female, mice.

This study investigates the role of dopamine D2 receptors in the bed nucleus of the stria terminalis (BNST) in modulating alcohol-related behaviors in male and female mice, finding sex-specific effects on alcohol consumption and pain sensitivity.

This study examines how acute and chronic alcohol exposure affects calcium dynamics in the extended amygdala, showing changes in neuronal activity and coherence in a sex-specific manner.

This study examines sex differences in BNST neuron function in rhesus macaques following chronic alcohol exposure, finding increased excitability and synaptic excitation in both sexes.

This study shows that retrieving an ethanol-conditioned taste aversion increases GABAergic plasticity in insular cortex-BLA projection neurons, with a male-specific role for parvalbumin-expressing interneurons.

This study examines gene expression changes in the CeA of male and female mice during acute and protracted abstinence from binge drinking, revealing sex-specific differences in gene regulation.

This study investigates the role of BNST 5HT2c receptor neurons in modulating alcohol self-administration behavior in mice, finding sex-dependent effects on alcohol seeking and aversive responses.

This study examines how chronic alcohol consumption affects hypothalamic CRH neurons in male and female mice during withdrawal, revealing sex-specific changes in stress responses and neuronal excitability.

This study shows that reducing GABA release from central amygdala neurotensin neurons decreases alcohol drinking in male mice but not females, with distinct behavioral effects in each sex.

This study investigates how insula dynorphin and kappa opioid receptor systems influence alcohol drinking in mice, revealing sex-specific effects on consumption and behavior.

The paper uses c-fos mapping and network analysis to show that alcohol dependence alters brain network activity during abstinence and reaccess in mice, with increased network modularity in high-drinking mice after reaccess.

This study identifies a serotonin-modulated GABAergic pathway from the vPAG to the CeA that enhances fear learning through 5HT2C receptor activation.

The paper demonstrates that activation of dorsal hippocampus to nucleus accumbens projections drives reinforcement via dynorphin neuron activity in the nucleus accumbens.

This study examines how chronic alcohol consumption affects behavior in mice during different predator threat tasks, revealing sex-specific changes in stress coping responses.

This study shows that activating the dorsal septum increases binge-like alcohol consumption in male mice, with sex-dependent effects on locomotor activity and sucrose drinking.

This study identifies sex-specific roles of serotonin 5HT2c receptor-containing neurons in binge drinking and affective behaviors using rodent models.

This study examines how TNF-α affects GABAergic and dopaminergic neurons in the ventral periaqueductal gray of female mice, showing differential changes in excitability and synaptic transmission.

The paper was retracted due to errors in methods and data reporting, making the results and conclusions unreliable.

This study identifies a sex-dependent glutamatergic circuit from the paraventricular thalamus to BNST CRF neurons that modulates binge drinking and avoidance behavior.