Yen‐Yu Ian Shih

SORDINO improves fMRI in awake mice by being silent, sensitive, specific, and resistant to motion artifacts, enabling better brain activity mapping.

The paper investigates excitation-inhibition balance dynamics in brain networks during naturalistic behavior in rats, finding coordinated E-I dynamics and transient imbalances linked to behavioral changes.

This study examines how acute alcohol consumption affects neural inhibition in both rats and humans using the Hurst exponent as an fMRI marker, finding reduced inhibition in both species.

CellPheno is a 3D nuclei segmentation tool for whole-brain microscopy that enables efficient morphometry and co-localization analysis across multiple cell types in mouse brains.

The paper assesses consistency of rat fMRI results across 12 centers using a unified pipeline and identifies variability due to experimental differences.

This study uses optogenetic fMRI to identify neural circuits affected by subthalamic nucleus deep brain stimulation in Parkinson's disease, finding that GP and CPu activity mediate therapeutic effects.

This study examines how acute and chronic alcohol exposure affects calcium dynamics in the extended amygdala, showing changes in neuronal activity and coherence in a sex-specific manner.

This study investigates the default mode network (DMN) in freely exploring rats, finding it dynamically encodes spatial exploration behaviors and challenges the notion of the DMN being task-negative.

This study identifies neurochemical influences on fMRI response polarity in the striatum, showing opioidergic transmission contributes to negative signals while dopaminergic transmission is associated with positive signals.

The paper investigates the neuronal dynamics of the rodent default mode network and its interaction with the anterior insular cortex, revealing how salient stimuli modulate these networks.

This paper introduces spectral fiber-photometry methods to correct hemoglobin absorption artifacts in fluorescent sensor recordings, improving accuracy in measuring neuronal activity.

This study uses optogenetic stimulation to show that anterior insular cortex neurons suppress default mode network activity and reduce its connectivity with the salience network in rats.

This study shows that chemogenetic activation of locus coeruleus norepinephrine neurons strengthens functional connectivity in the default mode network in mice.

This study shows that adolescent alcohol exposure reduces functional connectivity in brain networks involved in decision-making, which mediates deficits in behavioral flexibility in adulthood.

This paper combines fMRI and fast-scan cyclic voltammetry to measure oxygen and dopamine dynamics alongside BOLD signals, revealing strong correlations between tissue oxygen and BOLD and identifying dopamine-responsive brain regions.

This paper introduces a 3D U-Net framework for automatic brain extraction in rat MRI data, showing improved performance over existing methods.

The paper shows that a small number of dysregulated adult-born neurons in the hippocampus disrupt brain-wide functional connectivity and spatial memory.