Developmental BiologybioRxivPreprint
The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin
Yuxiang Zhang, Qian Sun, Zhiyong Ji…·Chencheng Yao
The paper identifies a missense variant in the XPF-like domain of SHOC1 that disrupts meiotic recombination and causes meiotic arrest by impairing DNA repair and chromatin structure.