Author

Ruhui Tian

Shanghai Jiao Tong UniversityORCID 0000-0001-5709-1175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Chencheng YaoiD· 4 shared Huixing Chen· 3 shared Liangyu ZhaoiD· 3 shared Zhi ZhouiD· 3 shared ChenChen WangiD· 2 shared Dewei QianiD· 2 shared Erlei ZhiiD· 2 shared Fujun ZhaoiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersDevelopmental Biology

Chencheng YaoORCID

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4 papers

Recent·Most cited

Molecular BiologyAdvanced SciencePeer-reviewedFeb 11, 2026

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Chenwang Zhang, Nan Liang, Wenbo Li…·Chencheng Yao

This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.

1 citation

mouseexperimental assay

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Developmental BiologybioRxivPreprintMay 28, 2025

The XPF-like domain in SHOC1 required for homologous recombination and safeguarding autosome from meiotic silencing of unsynapsed chromatin

Yuxiang Zhang, Qian Sun, Zhiyong Ji…·Chencheng Yao

The paper identifies a missense variant in the XPF-like domain of SHOC1 that disrupts meiotic recombination and causes meiotic arrest by impairing DNA repair and chromatin structure.

DOI 10.1101/2025.05.28.656576

mousehuman

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GenomicsbioRxivPreprintAug 26, 2020

Low XIST expression in Sertoli cells of Klinefelter syndrome patients caused the high susceptibility of these cells to an extra X chromosome

Liangyu Zhao, Peng Li, Chencheng Yao…·Zheng Li

DOI 10.1101/2020.08.26.269423

humanscRNA-seq

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Developmental BiologybioRxivPreprintMay 7, 2020

Single-cell atlas of human developing and azoospermia patients' testicles reveals the roadmap and defects in somatic microenvironment

Liangyu Zhao, Chencheng Yao, Xiaoyu Xing…·Zheng Li

This study creates a single-cell atlas of human testicular development and NOA patients, revealing Sertoli cell maturation defects and potential therapeutic strategies.

1 citation

humanscRNA-seq

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