Multiplexing droplet-based single cell RNA-sequencing using natural genetic barcodes
Hyun Min Kang, Meena Subramaniam, Sasha Targ, Michelle Ly Thai Nguyen, Lenka Maliskova, Elizabeth E. McCarthy, Eunice Wan, Simon Wong, Lauren E. Byrnes, Cristina M. Lanata, Rachel E. Gate, Sara Mostafavi, Alexander Marson, Noah Zaitlen, Lindsey A. Criswell, Chun Ye
The paper introduces demuxlet, an algorithm that uses natural genetic variation to multiplex single-cell RNA-seq samples, enabling accurate sample identification and doublet detection in pooled experiments.
Nature Biotechnology · Dec 11, 2017Peer-reviewedBioinformatics