Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
Ezequiel Miron, Roel Oldenkamp, Jill M. Brown, David Miguel Susano Pinto, C. Shan Xu, Ana Rita Faria, Haitham Ahmed Shaban, James Rhodes, Cassandravictoria Innocent, Sara De Ornellas, Harald F. Hess, Veronica J. Buckle, Lothar Schermelleh
The paper identifies linked chromatin domains (CDs) with nanoscale functional topography in somatic cells, showing cohesin and histone modifications are confined to surfaces and enriched in cores, independent of cohesin.
Science Advances · Sep 23, 2020Peer-reviewedGenomics