Roel Oldenkamp

Visualizing homology search in living cells

This study visualizes homology search dynamics in living human cells using GFP-MND1, revealing filament structures that resolve over time and depend on RAD54L and cohesin.

Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading

The paper visualizes Xist RNA dynamics in single cells during X chromosome inactivation using time-resolved structured illumination microscopy.

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin

The paper identifies linked chromatin domains (CDs) with nanoscale functional topography in somatic cells, showing cohesin and histone modifications are confined to surfaces and enriched in cores, independent of cohesin.

The CTCF Anatomy of Topologically Associating Domains

The paper investigates how CTCF site orientation relates to TAD structure by analyzing 4C data and spatial CTCF patterns, finding divergent sites at TAD boundaries and convergent sites within TADs.