GenomicsbioRxivPreprint
A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
Kevin M. Brown, Jun Zhong, Adriana Morales Miranda…·Tongwu Zhang
This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.