A Thiopurine-like Mutagenic Process Defines TGCT Subtypes
Kevin M. Brown, Jun Zhong, Adriana Morales Miranda, Mengyan Zhang, Joycelyn Williams, Jacob Williams, Haoyu Zhang, Liang Cheng C, Wenbo Li, Bin Zhu, Stephen Jacob Chanock, Katherine L. Nathanson, Tongwu Zhang
This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.
bioRxiv · Jun 12, 2025 · PreprintGenomics