Author

Alice C. Eastman

Johns Hopkins UniversityORCID 0000-0002-0103-0055Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Pion· 2 shared Erin W. KavanaghiD· 2 shared K. Starego· 2 shared Neeraj SharmaiD· 2 shared Adrianna L. BartolomucciiD· 1 shared Akshaya Vijaya AnnapragadaiD· 1 shared Alexandra N McKillop· 1 shared Alianna I. Parr· 1 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

A. Pion

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Author profile →

4 papers

Recent·Most cited

Structural variation in repeat elements is widespread in normal human tissues and in tumorigenesis

Akshaya Vijaya Annapragada, James White, Hope Orjuela, Adrianna L. Bartolomucci, Alice C. Eastman, Shashikant Koul, Kauí Patrício Lebarbenchon, Daniel C. Bruhm, Sarah Short, Keerti Boyapati, Noushin Niknafs, Carter Norton, Vishruth Girish, Nicholas A. Vulpescu, Sofia Velculescu, , Victor E. Velculescu

The paper identifies widespread mosaic structural variants in normal human tissues and tumors, with repeat-mediated variants impacting functional elements and enabling noninvasive tumor monitoring through cell-free DNA.

bioRxiv · Sep 28, 2026 · PreprintGenomics

CFTR function in nasal airway cells from symptomatic and asymptomatic CF heterozygotes

A. Pion, Alyssa Chang, Piero Mejia, Alice C. Eastman, Erin W. Kavanagh, Ana Topasna, K. Starego, Alianna Parr, Karen S. Raraigh, Christian Merlo, Neeraj Sharma, Garry Cutting

This study measures CFTR function in nasal airway cells from CF heterozygotes and controls, finding reduced CFTR activity in heterozygotes regardless of symptoms.

bioRxiv · Jun 18, 2026 · PreprintGenetics

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis

Erin W. Kavanagh, Anya T. Joynt, A. Pion, Alice C. Eastman, Alianna I. Parr, K. Starego, Manav Jain, Sydney R. Shannon, Edwin Yoo, Gregory A. Newby, Stephany Yi Tzeng, Neeraj Sharma, Jordan J. Green, Garry R. Cutting

This study corrects a CFTR splice site variant in airway cells using base editors and nanoparticles, showing increased CFTR expression and functional rescue in multiple cell types.

JCI Insight · May 7, 2026Peer-reviewedGenetics

The C. elegans SMOC-1 protein acts cell non-autonomously to promote bone morphogenetic protein signaling

Melisa S. DeGroot, Herong Shi, Alice C. Eastman, Alexandra N McKillop, Jun Liu

This study identifies SMOC-1 as a positive modulator of BMP signaling in C. elegans, showing it acts cell non-autonomously and is evolutionarily conserved.

Genetics · Dec 5, 2018Peer-reviewedGenetics