Author

Hope Orjuela

Cold Spring Harbor LaboratoryORCID 0000-0001-8458-8080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrianna L. BartolomucciiD· 1 shared Akshaya Vijaya AnnapragadaiD· 1 shared Alice C. EastmaniD· 1 shared Andrew Nelson· 1 shared Arvind RishiiD· 1 shared Boris J. N. WinterhoffiD· 1 shared Carter Norton· 1 shared Craig Podszus· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adrianna L. BartolomucciORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 28, 2026

Structural variation in repeat elements is widespread in normal human tissues and in tumorigenesis

Akshaya Vijaya Annapragada, James White, Hope Orjuela…·Victor E. Velculescu

The paper identifies widespread mosaic structural variants in normal human tissues and tumors, with repeat-mediated variants impacting functional elements and enabling noninvasive tumor monitoring through cell-free DNA.

DOI 10.64898/2026.09.22.753313

humanwhole-genome sequencing

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GenomicsbioRxivPreprintOct 4, 2023

DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples

Siran Li, Joan Alexander, Jude Kendall…·Dan Levy

This study introduces hybrid BAG-seq to analyze DNA and RNA from single nuclei in tumor samples, revealing genome-transcriptome interactions and tumor heterogeneity.

4 citations

humanDNA methylation

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