Dual Control of Low-Density Lipoprotein Cholesterol Levels by ANGPTL3 and ANGPTL8
Yanqing Xu, Fei Luo, Justin A. Fletcher, Melissa R. Iñigo, Shawn C. Burgess, Guosheng Liang, Lisa N. Kinch, Julia Kozlitina, Jonathan C. Cohen, Helen H. Hobbs
This study investigates how ANGPTL3 and ANGPTL8 regulate LDL cholesterol levels through their cleavage products and interactions with lipases, showing that both proteins are required for maximal lipolysis inhibition.
bioRxiv · Apr 1, 2026 · PreprintMolecular Biology