Shawn C. Burgess

Traumatic brain injury alters hepatic gluconeogenic metabolism assessed using hyperpolarized pyruvate

This study uses hyperpolarized pyruvate to show traumatic brain injury increases hepatic gluconeogenic metabolism in fasted rats.

Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

Dual Control of Low-Density Lipoprotein Cholesterol Levels by ANGPTL3 and ANGPTL8

This study investigates how ANGPTL3 and ANGPTL8 regulate LDL cholesterol levels through their cleavage products and interactions with lipases, showing that both proteins are required for maximal lipolysis inhibition.

Glucose-dependent metabolism of hippocampal primary neurons in response to chemically induced long-term potentiation

This study investigates how physiological versus high glucose conditions affect neuronal metabolism and synaptic plasticity during long-term potentiation.

Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.

Valine and Inflammation Drive Epilepsy in a Mouse Model of ECHS1 Deficiency

This paper develops a mouse model of ECHS1 deficiency and identifies valine metabolism and inflammation as drivers of epilepsy in the disease.