Helen H. Hobbs

TM6SF2 is a cholesterol-bound homomultimeric ER membrane protein that binds ApoB and is required for bulk lipidation of VLDL

This study determines the structure of TM6SF2 and shows its role in lipidation of ApoB-containing lipoproteins, with a variant affecting cholesterol binding and function.

Structure and Function of TM6SF1 Reveal Role in mTORC1 Signaling

This study determines the cryo-EM structure of TM6SF1 and shows it regulates mTORC1 signaling through cholesterol-dependent interaction with LAMTOR1, affecting TFEB activation.

Dual Control of Low-Density Lipoprotein Cholesterol Levels by ANGPTL3 and ANGPTL8

This study investigates how ANGPTL3 and ANGPTL8 regulate LDL cholesterol levels through their cleavage products and interactions with lipases, showing that both proteins are required for maximal lipolysis inhibition.

Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges

This study investigates tissue-specific regulation of PNPLA3 in mice, showing feeding increases hepatic PNPLA3 while cold exposure boosts it in brown adipose tissue through post-transcriptional mechanisms, linking it to lipid remodeling in response to metabolic stress.

PNPLA3(148M) Promotes Hepatic Steatosis by Interfering with Triglyceride Hydrolysis Through a Gain-of-Function Mechanism

ABHD5 binds PNPLA3 more strongly than ATGL regardless of the I148M variant; steatosis from PNPLA3(148M) needs ATGL and is reversed by ABHD5 overexpression.