Molecular BiologybioRxivPreprint
MSK-mediated phosphorylation of Histone 3 Ser28 couples MAPK signaling with early gene induction and cardiac hypertrophy
Emma Louise Robinson, Faye Drawnel, Saher Mehdi…·H. Llewelyn Roderick
The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.